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Parkridge Medical Center
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Parkridge East Hospital
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Acute Interstitial Nephritis

Definition

Acute interstitial nephritis is a kidney disorder. The kidneys are unable to filter waste and fluid properly because of inflammation.

Anatomy of the Kidney
Glomerulonephritis
Copyright © Nucleus Medical Media, Inc.

Causes

Acute interstitial nephritis can be caused by:

Risk Factors

Factors that may increase your chance of acute interstitial nephritis include:

  • Drug or medication use (adults)
  • Infection (children)

Symptoms

Acute interstitial nephritis may cause:

  • Decrease in urine output
  • Blood in urine
  • Side or loin pain
  • Swelling of the body
  • Nausea and vomiting
  • Loss of appetite
  • Weakness
  • Aching joints
  • Fever
  • Rash

Diagnosis

Your doctor will ask about your symptoms and medical history. A physical exam will be done. Tests may include:

  • Blood Tests
  • Urine tests
  • Kidney ultrasound
  • Kidney biopsy—may be done before certain medications are prescribed for treatment

Treatment

Talk with your doctor about the best treatment plan for you. Treatment will depend on the cause. For example, if medications are causing acute interstitial nephritis, your doctor may stop the medication, reduce the dosage, or prescribe a different one.

Treatment options include the following:

Medications

Medications for acute interstitial nephritis may include:

  • Antibiotics for bacterial infection
  • Corticosteroids to reduce inflammation

Dialysis

Some people with interstitial nephritis need dialysis. During dialysis, a machine does the work of your kidneys by removing waste from the blood.

Prevention

To help reduce your chances of acute interstitial nephritis, your doctor may suggest you avoid certain medications, such as penicillin or NSAIDs.

Revision Information

  • National Institute of Diabetes and Digestive and Kidney Diseases

    http://www.niddk.nih.gov

  • National Kidney Foundation

    http://www.kidney.org

  • Health Canada

    http://www.hc-sc.gc.ca

  • Kidney Foundation of Canada

    http://www.kidney.ca

  • Acute interstitial nephritis. DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated December 9, 2014. Accessed May 8, 2015.

  • Kodner CM, Kudrimoti A. Diagnosis and management of acute interstitial nephritis. Am Fam Physician. 2003;67(12):2527-2534.

  • Plakoglannis R, Nogid A. Acute interstitial nephritis associated with coadministration of vancomycin and ceftriaxone: Case series and review of the literature. Pharmacotherapy. 2007:27(10):1456-1461.

  • Sierra F, Suzrez M, Rey M, Vela MF. Systematic review: Proton pump inhibitor-associated acute interstitial nephritis. Aliment Pharmaco Ther. 2007:26:545-553.